Clinical Monograph: Urivera™ Suspension
​Therapeutic Class: Urinary Tract Health / Nutraceutical Urinary Alkalizer.
​Overview: ​Urivera™ is a synergistic combination designed to support urinary tract health and manage recurring Urinary Tract Infections (UTIs). It combines the bacterial anti-adhesion properties of Cranberry and D-Mannose with the systemic alkalizing effects of Potassium Magnesium Citrate.
​Composition
​Each 15ml of Urivera™ Suspension contains:
1.​Cranberry Extract (Standardized for PACs): 200 mg
2.​D-Mannose: 300 mg
​3. Potassium Magnesium Citrate: 975 mg
4.​ Flavor: Cherry
​5. Base: Sugar-Free (Suitable for Diabetic Patients)
​Pharmacodynamics & Mechanism of Action
​1. Cranberry Extract (Proanthocyanidins – PACs). ​Cranberry contains Type-A Proanthocyanidins which inhibit the p-fimbriae of Escherichia coli (E. coli) from adhering to the uroepithelial cells. By preventing colonization, it facilitates the flushing out of bacteria during micturition.
​2. D-Mannose: ​D-Mannose is a simple sugar that is primarily excreted unchanged in the urine. It acts as a “decoy” for E. coli. The bacteria bind to the D-Mannose molecules instead of the bladder wall, forming a complex that is easily voided.
​3. Potassium Magnesium Citrate ​Acts as a systemic alkalizer.

​PH Modulation: It increases urinary pH, making the environment less hospitable for certain bacteria and providing symptomatic relief from burning micturition (dysuria).
​Lithogenic Inhibition: It increases urinary citrate levels, which helps inhibit the crystallization of stone-forming salts like calcium oxalate and calcium phosphate.
​Indications
​Management and prophylaxis of recurrent Urinary Tract Infections (UTIs).
​Symptomatic relief from Burning Micturition (Dysuria).
​Prevention of Urolithiasis (especially calcium oxalate stones).
​Adjuvant therapy alongside antibiotics in acute UTI.
​Dosage and Administration
​For Adults: 10ml (one measuring cup) diluted in a glass of water, twice daily, or as directed by the physician.
​Note: Increased water intake is recommended during therapy to enhance the “flushing” effect.
​Clinical Advantages
​Synergistic Action: Dual-action anti-adhesion (Cranberry + D-Mannose) reduces dependency on long-term prophylactic antibiotics.
​Symptom Management: Rapidly neutralizes acidic urine to reduce pain and urgency.
​Patient Compliance: Pleasant cherry flavor with a sugar-free formulation ensures better adherence, even in geriatric or diabetic populations.
​Precautions & Side Effects
​Contraindications: Severe renal impairment or hyperkalemia.
​Side Effects: Generally well-tolerated; mild gastrointestinal upset or laxative effect may occur in sensitive individuals.
​Drug Interactions: Use with caution in patients taking Potassium-Sparing Diuretics or ACE inhibitors due to the potassium content.